NSAIDs in cardiovascular diseases
NSAIDs in cardiovascular diseases
Madalas nagtatanong ang mga tao sa mga botika tungkol sa mga gamot laban sa presyon ng bagong henerasyon na walang side effects. Pero sa totoong buhay, hindi ito nangyayari. Lahat ng epektibong gamot ay may kanya-kanyang side effects. Kailangan mong maglaan ng maraming oras kasama ang iyong doktor para piliin ang tamang grupo ng gamot laban sa high blood pressure para sa'yo.
ЧИТАТЬ ДАЛЕЕ ...
NSAIDs in cardiovascular disease: risks and clinical implicationsNon-steroidal anti-inflammatory Drugs (NSAIDs) are among the most commonly used drugs worldwide and are mainly used for the treatment of pain, inflammation and fever. Despite their wide distribution and OTC availability (over‑the‑counter) you are associated with a number of side effects, particularly in patients with existing cardiovascular disease (CVD).Pharmacological mechanisms of action and cardiovascular effectsThe effect of the NSAIDs is based on the inhibition of the Cyclooxygenase enzymes (COX‑1 and COX‑2), for the synthesis of prostaglandins responsible. Prostaglandins play an important role in the Regulation of vascular tone, platelet aggregation and Renal blood flow. The selective or non-selective inhibition of these enzymes can trigger the following cardiovascular effects:Increase in blood pressure through a reduction in vasodilator of prostaglandins and decreased renal function.Fluid retention: due to changes in renal perfusion and increased sodium retention.Thromboembolic events: in particular, in the case of selective COX‑2 inhibitors, which affect platelet function less, but the production of prostacyclin (PGI₂) in the vessel to inhibit walls.Epidemiological EvidenceSeveral large observational studies and meta-analyses have shown that the intake is associated with the NSAIDs with an increased risk for cardiovascular events. In particular:an increased risk for myocardial infarction (MI),a higher incidence of stroke,an increase of congestive heart failure exacerbations,a possible risk for arrhythmic events.The risk seems to be dose and duration of intake and the specific NSAIDs to hang out. For example, it was described for Diclofenac significantly higher cardiovascular risk than for Naproxen.Risk groupsParticularly patients with risk:of existing coronary heart disease (CHD),arterial hypertension,Diabetes mellitus,chronic renal failureCongestive heart failure.Also, elderly patients are exposed to due to Comorbidities and altered pharmacokinetics with an increased risk.Clinical RecommendationsBefore the regulation of NSAIDs, a careful Benefit-risk assessment should be performed, especially in patients with CVD or elevated cardiovascular risk profile. Recommendations include:The lowest effective dose for the shortest possible duration.Waiver of COX‑2‑selective inhibitors in patients with hollow cardiovascular risk.Preference for Naproxen in some cases, because it has a more favourable cardiovascular profile (but with an increased gastrointestinal risk).Regular monitoring of blood pressure, of renal function, and of Edema during therapy.Educating the patients about the symptoms of cardiovascular complications (e.g., chest pain, shortness of breath, sudden swelling).ConclusionNSAIDs can cause in patients with cardiovascular disease to significant cardiovascular side effects. An individual risk assessment in a differentiated Medicines selection and close Monitoring are crucial to ensure the safety of these drugs in clinical practice. Further research is needed to understand the long-term effects of various NSAIDs on the cardiovascular System.
Madalas nagtatanong ang mga tao sa mga botika tungkol sa mga gamot laban sa presyon ng bagong henerasyon na walang side effects. Pero sa totoong buhay, hindi ito nangyayari. Lahat ng epektibong gamot ay may kanya-kanyang side effects. Kailangan mong maglaan ng maraming oras kasama ang iyong doktor para piliin ang tamang grupo ng gamot laban sa high blood pressure para sa'yo. NSAIDs in cardiovascular diseases. Minsan lang na biglaang pagtaas ng presyon o bahagyang mataas na resulta ay hindi palaging nangangailangan ng agarang pag-inom ng tableta. Lahat ng rekomendasyon ng mga espesyalista at ang mga magagamit na paraan ng pag-iwas ay mukhang simple lang, pero sa aktwal na buhay, ang maingat na pag-aalaga sa kalusugan ng dugo at sistema ng puso ay nakakaiwas sa biglaan at sobrang hindi kanais-nais na pagtaas ng presyon.
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A sedentary lifestyle, alcohol, and cigarette consumption increase body weight which in turn hinders healthy blood circulation and strength of arteries and veins. This results in high blood pressure. So, if you’re overweight, you need to monitor your blood pressure frequently. Ginagamit ito bilang biologically active na pampadagdag sa pagkain — dagdag na pinagmumulan ng mga bitamina — B2, B6, C, mga organikong asido — mansanas, succinic, glutamine. Mga sangkap: malic acid, succinic acid, glutamic acid, badan extract, ascorbic acid, bitamina B2, B6.
Diseases of the cardiovascular system: A silent threatThe cardiovascular System is the life-center of our body: It ensures that oxygen and nutrients to all organs and waste products to be removed. But it is precisely this vital function makes it particularly susceptible to System — diseases of the cardiovascular system are among the most common causes of death.What is circulatory System?First, a brief look at the structure of The cardiovascular System includes the heart as a Central pumping mechanism as well as an extensive network of blood vessels — arteries, veins, and capillaries. Each component can be affected by diseases.List of the most important diseasesAn Overview of the most common clinical pictures:Coronary heart disease (CHD). By calcification of the coronary arteries (atherosclerosis) is impaired blood flow to the heart muscle. Symptoms such as Angina pectoris (chest pain) or a heart attack are possible consequences.Heart attack. An acute closure of a heart vessel leads to the death of heart muscle tissue. Pain in the chest, shortness of breath, and Nausea are typical signs.Congestive heart failure. The heart loses its Capacity and is no longer able to provide the body with sufficient blood. Fatigue, swelling in the legs and shortness of breath are common complaints.High Blood Pressure (Hypertension). A permanently elevated blood pressure is damaging in the long term, heart, and vessels and increases the risk for stroke and heart attack.Stroke (Apoplexy). By a Vascular occlusion or tear in the brain, the blood flow is interrupted. This can lead to permanent damage or death.Arrhythmias. Disorders of the heart rhythm, such as atrial fibrillation or ventricular fibrillation, can lead to irregular heartbeat and the risk of thrombosis and stroke increase.Valve defects. Defects of the heart valves (e.g., aortic stenosis) disrupt the normal flow of blood through the heart and can lead to Overload and heart failure.Peripheral arterial occlusive disease (paod). Narrowing of the arteries outside the heart, usually in the legs can lead to pain when walking (miracles) and increase the risk of wound healing disorders.Cardiomyopathies. Diseases of the heart muscle, which can impair its function, independent of hypertension or coronary artery disease.Inflammation of the heart. Myocarditis (inflammation of the heart muscle), endocarditis (inflammation of the heart lining) or pericarditis (inflammation of pericardium) may be triggered by viruses, bacteria, or autoimmune reactions.Prevention: What can we each do?Many of these diseases through a healthy lifestyle can prevent or at least significantly weaken:Regular physical activityA balanced diet with lots of vegetables, fruit and fiberWaiver of Smoking and excess alcohol consumptionStress management and adequate sleepRegular checks of blood pressure, cholesterol and blood sugarConclusionHe early detection and a conscious way of life, the best weapon against diseases of the cardiovascular system. Who takes responsibility for his health, you can improve the quality of life and long term, and the silent threat at an early stage debunk.